Extracts of paw paw (Asimina triloba, Annonaceae family) have strong anti-cancer activity. The paw paw is a small tree with edible fruit native to eastern North America. The annonaceous acetogenins ... more

Artemisinin is a compound isolated from a species of wormwood, Artemisia annua L. It reacts with iron and forms cytotoxic free radicals which accumulate inside cancer cells and help to ... more

Extracts of the rootstock of Black cohosh contain biologically active constituents as triterpene glycosides (actein, cimicifugoside, deoxyacetein), isoferulic acid and alkaloids (n-methylcytisine). Recent data has demonstrated that Black Cohosh may ... more

The following studies suggest that meditation can decrease the likelihood of recurrence of cancer. A mindfulness meditation program was effective in decreasing mood disturbance and stress symptoms in both male ... more

Women who are both physically active, exercising for 30 minutes daily (walking) 6 days a week and who consume 6 servings of fruits and vegetables daily can reduce their risk ... more

The birth control pill (BCP) or oral contraceptives, when used before age 20, significantly increase risk of early-onset breast cancer (diagnosed before age 36). If the BCP is used consistently ... more

Studies have shown an increase in breast cancer risk among women who have elevated levels of testosterone, reduced levels of sex hormone-binding globulin (SHBG), and therefore elevated levels of bioavailable ... more

Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates. Effect of selenium in combination with Adriamycin or Taxol on several different ... more

Animal studies demonstrate that fermented miso protects against the effects of radiation.   Radioprotective effects of miso (fermented soy bean paste) against radiation in B6C3F1 mice: increased small intestinal crypt survival, crypt ... more

When given with the chemotherapy drug Doxorubicin, which can damage heart muscle, melatonin protects heart cells from damage by raising glutathione levels and stimulating catalase activity. (Catalase is an enzyme ... more

In a study on mice with ovarian cancer, theanine (found in green tea) enhanced the inhibitory effect of the chemotherapy drug Doxorubicin on tumor growth and increased the Doxorubicin concentration ... more

Prospective Multicenter Study of the Impact of the 21-Gene Recurrence Score Assay on Medical Oncologist and Patient Adjuvant Breast Cancer Treatment Selection. Ki67 expression and docetaxel efficacy in patients ... more

Some selective serotonin reuptake inhibitor (SSRI) antidepressants, such as Paxil (Paroxetine), reduce tamoxifen's effectiveness by inhibiting its bioactivation by cytochrome P450 2D6 (CYP2D6). Paroxetine use during tamoxifen treatment is associated ... more

Fifty human clinical randomized or observational trials have been conducted, involving 8,521 patients using beta-carotene; vitamins A, C, and E; selenium; cysteine; B vitamins; vitamin D3; vitamin K3; and glutathione ... more

Mercuric chloride exerts an estrogenic effect through binding to the estrogen receptor that can cause human breast cancer cells to proliferate. The heavy metals iron, nickel, chromium, zinc, cadmium, mercury, ... more

Ultraviolet sunscreens are increasingly used to protect from ultraviolet radiation and skin cancer. They are often added to cosmetics and other products for light stability. However, many of the chemicals ... more

Phthalates are ubiquitous, carcinogenic estrogenic chemicals that contaminate food, indoor air, soil, sediment and drinking water. They are added to plastics to make them soft, to polyvinyl chloride (PVC) products ... more

Polychlorinated Biphenyls are synthetic chlorinated hydrocarbon compounds whose commercial production started in the thirties. They have been widely used in the electro-technical industry. Mammals continue to be exposed to the ... more

The parabens are phenolic compounds used as preservatives in 22,000 cosmetics, toothpaste, shampoos, conditioners etc. They include methylparaben, ethylparaben, propylparaben, butylparaben, isopropylparaben and isobutylparaben. They all weakly stimulate growth of ... more

Bisphenol A (BPA) is used in manufacturing a wide range of chemical products which include epoxy resins and polycarbonate (hard plastics). BPA increases the cell proliferation activity of human breast ... more