Breast Cancer and Parabens

ToothpasteonbrushThe parabens are phenolic compounds used as preservatives in 22,000 cosmetics, toothpaste, shampoos, conditioners etc. They include methylparaben, ethylparaben, propylparaben, butylparaben, isopropylparaben and isobutylparaben. They all weakly stimulate growth of breast cancer cells and are able to bind to both ERalpha and ERbeta receptors with methylparaben acting at 1/1000 of the strength as estradiol. Parabens can be absorbed intact through the skin. There is a need to carry out detailed evaluation of parabens’ potential ability to promote female breast cancer, to interfere with male reproductive functions, and to cause malignant melanoma.

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