Genistein from soy in combination with capsaicin from cayenne pepper, and curcumin from turmeric, decrease inflammation and reduce growth in breast cancer cells. EGCG, an ingredient in green tea (highest in matcha green tea powder), also suppresses breast cancer cell growth by inhibiting angiogenesis.
Angiogenesis refers to the formation of a blood supply that feeds cancerous tumours. In breast cancer, angiogenesis is initiated at the onset of hyperplasia in the mammary duct, although the greatest increase in angiogenesis occurs with the development of invasion of the cancer into the surrounding tissues.
- Anti-inflammatory and anticarcinogenic effect of genistein alone or in combination with capsaicin in TPA-treated rat mammary glands or mammary cancer cell line.
- Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease.
- Effect of curcumin on pro-angiogenic factors in the xenograft model of breast cancer.
- EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1α and NFκB, and VEGF expression.